A 40-car train headed from Memphis to Savannah derailed near Beach Highway in Ware County, northwest of Waycross, Thursday about 5 p.m..
Three containers carrying Seagrams liquor were reported damaged and leaking.
Crews were cleaning up the spillage.
Some crews from the Environmental Protection Agency were also spotted on site.
No one was hurt.
CSX said they likely won’t have the scene cleared until 6 a.m.